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AKA-29
Cepharanthine
Cat. No.
AKA-29
CAS No.
481-49-2
MF
C37H38N2O6
MW
606.71
Cepharanthine is a natural alkaloid that inhibits TNF‑α‑mediated NFκB stimulation, plasma membrane lipid peroxidation, platelet aggregation and the production of cytokines.
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Technical Data
Description
Storage and Shipping
References
Product Name
Cepharanthine
CAS No.
481-49-2
MF
C37H38N2O6
MW
606.71
Specification
API
Research Area
Oncology, Anti-infection
Description
Cepharanthine is a natural alkaloid that inhibits TNF‑α‑mediated NFκB stimulation, plasma membrane lipid peroxidation, platelet aggregation and the production of cytokines. Packing: 10g/vial; 100g/bag; 1kg/bag; 5kg/drum or as request Availability: In stock
Documents
Certificate of Analysis (COA), API specification, Safety Data Sheet (SDS/MSDS), evidence of GMP compliance, Stability data / Stability summary, etc.
Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Hijikata A, et al. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS Open Bio. 2022;12(1):285-294
[2]. Shen LW, et.al. Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis. Acta Pharmacologica Sinica. 2022 Jan;43(1):177-193.
[3]. Ikeda R, et.al. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Science. 2005 Jun;96(6):372-6.
[4]. Zhang X, et.al. In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes. Pharmaceutical Biology. 2020 Dec;58(1):247-252.
[5]. Hua P, et.al. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. Biochemical and Biophysical Research Communications. 2015 May 1;460(2):136-42.
[6]. Desgrouas C, et.al. In vitro antiplasmodial activity of cepharanthine. Malaria Journal. 2014 Aug 22;13:327.
[7]. Murakami K, et.al. The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats. American Journal of Respiratory and Critical Care Medicine. 2000 Jan;161(1):57-63.
[8]. Wei XY, et,al. Antinociceptive activities and mechanism of action of Cepharanthine. Biochemical and Biophysical Research Communications. 2022 Jul 23;614:219-224.
[2]. Shen LW, et.al. Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis. Acta Pharmacologica Sinica. 2022 Jan;43(1):177-193.
[3]. Ikeda R, et.al. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Science. 2005 Jun;96(6):372-6.
[4]. Zhang X, et.al. In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes. Pharmaceutical Biology. 2020 Dec;58(1):247-252.
[5]. Hua P, et.al. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. Biochemical and Biophysical Research Communications. 2015 May 1;460(2):136-42.
[6]. Desgrouas C, et.al. In vitro antiplasmodial activity of cepharanthine. Malaria Journal. 2014 Aug 22;13:327.
[7]. Murakami K, et.al. The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats. American Journal of Respiratory and Critical Care Medicine. 2000 Jan;161(1):57-63.
[8]. Wei XY, et,al. Antinociceptive activities and mechanism of action of Cepharanthine. Biochemical and Biophysical Research Communications. 2022 Jul 23;614:219-224.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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